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>> Fee Download The Practice of Medicinal ChemistryFrom Academic Press

Fee Download The Practice of Medicinal ChemistryFrom Academic Press

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The Practice of Medicinal ChemistryFrom Academic Press

The Practice of Medicinal ChemistryFrom Academic Press



The Practice of Medicinal ChemistryFrom Academic Press

Fee Download The Practice of Medicinal ChemistryFrom Academic Press

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The Practice of Medicinal ChemistryFrom Academic Press

The Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process.

* The only book available dealing with the practical aspects of medicinal chemistry
* Serves as a complete guide to the drug discovery process, from conception of the molecules to drug production
* Updated chapters devoted to the discovery of new lead compounds, including combinatorial chemistry

  • Published on: 2003-06-11
  • Released on: 2003-06-11
  • Format: Kindle eBook

Review
"...it is a practical guide with many examples from the recent literature...it serves as an excellent introduction to those just starting a career in medicinal chemistry...Because these chapters are organized as reviews, they will serve as a good resource for those already working as medicinal chemists. The chapter on natural products provides an interesting analysis of marketed drugs and compounds in the clinic that supports their use as an important source of leads. In summary, this is a book that should be included in the libraries of companies and institutions where medicinal chemistry in practiced."
-John W. Ellingboe, Wyeth Research, New York

"The Practice of Medicinal Chemistry is highly recommended for medical libraries and academic libraries that support a chemistry program."
-E-STREAMS (May 2004)

"Practicing medicinal chemists, particularly those within five years of their first post-school appointment in the area, will profit from buying and studying this book. Pharmacologists and others interacting with medicinal chemists will also find this book to be useful in their professional work. Those who liked the first edition will like this one even better."
-DOODY'S (March 2004)

"...capture[s] the whole spectrum of activities associated with both the theory and practice of rational drug design. ...an impressive book suitable for not only Medicinal Chemists of all experience levels but for anyone working in the field of drug discovery. It would be a welcome addition to any drug discoverer's book shelf."
-BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2003)
PRAISE FOR THE FIRST EDITION


"...a useful, authoritative discussion of the principles and practice of medicinal chemistry...the volume has a useful index, is well produced, and is very resonably priced..."
-JOURNAL OF MEDICINAL CHEMISTRY

About the Author
Camille-Georges Wermuth PhD, Prof. and Founder of Prestwick Chemical, was Professor of Organic Chemistry and Medicinal Chemistry at the Faculty of Pharmacy, Louis Pasteur University, Strasbourg, France from 1969 to 2002. He became interested in Medicinal Chemistry during his two years of military service in the French Navy at the "Centre d'Etudes Physio-biologiques Appliquées à la Marine" in Toulon. During this time he worked under the supervision of Dr Henri Laborit, the scientist who invented artificial hibernation and discovered chlorpromazine.

Professor Wermuths' main research themes focus on the chemistry and the pharmacology of pyridazine derivatives. The 3-aminopyridazine pharmacophore, in particular, allowed him to accede to an impressive variety of biological activities, including antidepressant and anticonvulsant molecules; inhibitors of enzymes such as mono-amine-oxidases, phosphodiesterases and acetylcholinesterase; ligands for neuro-receptors: GABA-A receptor antagonists, serotonine 5-HT3 receptor antagonists, dopaminergic and muscarinic agonists. More recently, in collaboration with the scientists of the Sanofi Company, he developed potent antagonists of the 41 amino-acid neuropeptide CRF (corticotrophin-releasing factor) which regulates the release of ACTH and thus the synthesis of corticoids in the adrenal glands. Professor Wermuth has also, in collaboration with Professor Jean-Charles Schwartz and Doctor Pierre Sokoloff (INSERM, Paris), developed selective ligands of the newly discovered dopamine D3 receptor. After a three-year exploratory phase, this research has led to nanomolar partial agonists which may prove useful in the treatment of the cocaine-withdrawal syndrome.

Besides about 300 scientific papers and about 60 patents, Professor Wermuth is co-author or editor of several books including; Pharmacologie Moléculaire, Masson & Cie, Paris; Médicaments Organiques de Synthèse, Masson & Cie, Paris; Medicinal Chemistry for the 21st Century, Bl

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